بررسی رابطه سطح لیپیدهای سرم با پره اکلامپسی

Background and purpose : Pregnancy may cause hypertension in normotensive women or aggrevate preexisting hypertention. The incidence of Preeclamsia is 5-10%, and is an important contributor to maternal and fetal mortality and morbidity. According to many predisposing factors in pathophysiology of preeclampsia, the role of lipid preoxides, is also important. In this study attempts are made to show the relationship between inceasing of plasma lipids and hypertension in pregnancy. Materials and Methods : This is a case-control study on pregnant women reffering to Sari Imam Khomeini Hospital, From Oct. 2003 to Oct. 2004. Case group include 100 preeclamptic pregnant women and for control group 100 normotensive pregnant women were recruired. (preeclamsia : BP> = 140 /90 mmHg, or Proteinuria > + 1 0r > = 300mg/dL in urine 24 h ) . Total TG, cholestrol, HDL and LDL were measured by enzymatic methods. Statistical analysis were performed using T-Test and Pearson's method. Results : The most important results are as follows: The mean of TG in case group was 45 % more than that of the control group (P<0.001, sig). The mean of cholestrol level in case group was 15 % more than control group (P<0.01, sig). The mean of LDL in case group is 5 % more than that of the control group (NS). Conclusion : As the levels of plasma lipids in preeclamptic women were more than normotensive women measuring of Plasma lipids also can be a marker for predisposing to Preeclampsia.